[Human pharmacology of ceftriaxone (author's transl)].

The human pharmacology of ceftriaxone was studied in five healthy adult subjects receiving a 500 mg dose intravenously. Evolution of serum levels represents a two compartment open model; the distribution volumes, central and peripheric, were low (about 3 L); the elimination half-life was particularly long : 7.87 hours; the renal and serum clearances and low. These data are probably related to the high affinity of the drug for serum proteins (95 p. cent bound); they suggest once daily parenteral dosing.