培养的人成纤维细胞中胶原蛋白与C1q生物合成之间的关系。
The relationship between collagen and C1q biosynthesis in cultured human fibroblasts.
作者信息
Fleming K A, McGee J O
出版信息
Biochem J. 1982 Aug 15;206(2):287-93. doi: 10.1042/bj2060287.
Abstract
The relationship between collagen and C1q biosynthesis has been investigated in cultured human fibroblasts. This was done by measuring the effects of variation in cell density, inhibition of prolyl hydroxylase and complexing of C1q on synthesis and/or secretion of both proteins. It was found that synthesis and secretion of both proteins were not co-ordinate, and that therefore regulation of expression of both proteins is probably not linked. However complexing of C1q did result in marked stimulation in collagen synthesis, suggesting that the fibrosis which follows inflammation may result from binding of C1q to the immune complexes formed in the inflammatory process.
摘要
在培养的人成纤维细胞中研究了胶原蛋白与C1q生物合成之间的关系。这是通过测量细胞密度变化、脯氨酰羟化酶抑制以及C1q复合对这两种蛋白质合成和/或分泌的影响来完成的。发现这两种蛋白质的合成和分泌不协调，因此这两种蛋白质表达的调节可能没有联系。然而，C1q的复合确实导致胶原蛋白合成受到显著刺激，这表明炎症后发生的纤维化可能是由于C1q与炎症过程中形成的免疫复合物结合所致。
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