Synthesis and properties of beta h-endorphin analogs containing the dynorphin-(1-13) sequence.
作者信息
Li C H, Yamashiro D, Ferrara P, Tseng L F, Way E L
出版信息
Int J Pept Protein Res. 1983 Apr;21(4):331-5. doi: 10.1111/j.1399-3011.1983.tb03112.x.
Abstract
Two analogs of beta h-endorphin containing dynorphin-(5-13) or dynorphin-(6-13) sequence have been synthesized by the solid-phase method. Biological activities of the analogs have also been investigated. It was found that the opiate activity is about three times more than beta h-endorphin in the guinea pig ileum assay. Both analgesic potency and opiate receptor-binding activity of the analogs are lower when compared with beta h-endorphin. However, the analogs have interesting behavioral effects in mice.
摘要
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