马流感灭活疫苗的研究。2. 针对A/马/纽马基特/79（H3N8）流感病毒实验性感染的防护作用
Studies with inactivated equine influenza vaccine. 2. Protection against experimental infection with influenza virus A/equine/Newmarket/79 (H3N8).
作者信息
Mumford J, Wood J M, Scott A M, Folkers C, Schild G C
出版信息
J Hyg (Lond). 1983 Jun;90(3):385-95. doi: 10.1017/s0022172400029016.
Abstract
Forty ponies immunized with inactivated virus vaccine containing A/equine/Miami/63 (H3N8) virus and six unvaccinated, seronegative ponies were experimentally challenged with a representative of recent equine H3N8 virus isolates, A/equine/Newmarket/79. All unvaccinated ponies became infected as judged by virus excretion, febrile responses and antibody responses, but only two of the vaccinated ponies were fully protected. Pre-challenge antibody levels to A/Newmarket/79 virus detected by single radial haemolysis (SRH) correlated well with the degree of clinical protection but the levels required for complete protection (SRH zones greater than 65 mm2) were high. The importance of these results in relation to conventional vaccination procedures against equine influenza is discussed.
摘要
40匹用含A/equine/Miami/63（H3N8）病毒的灭活病毒疫苗免疫的小马和6匹未接种疫苗、血清学阴性的小马，用近期马H3N8病毒分离株的代表株A/equine/Newmarket/79进行实验性攻毒。根据病毒排泄、发热反应和抗体反应判断，所有未接种疫苗的小马均被感染，但只有2匹接种疫苗的小马得到了完全保护。通过单扩散溶血试验（SRH）检测到的攻毒前针对A/Newmarket/79病毒的抗体水平与临床保护程度密切相关，但完全保护所需的水平（SRH区大于65平方毫米）很高。讨论了这些结果与常规马流感疫苗接种程序的相关性。
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