石棉对不同活化状态巨噬细胞的细胞毒性作用。
Cytotoxic effect of asbestos on macrophages in different activation states.
作者信息
Wright A, Donaldson K, Davis J M
出版信息
Environ Health Perspect. 1983 Sep;51:147-52. doi: 10.1289/ehp.8351147.
Abstract
The in vitro effects due to phagocytosis of asbestos by mouse peritoneal macrophages in various stages of activation have been compared. The amphiboles proved relatively inert; chrysotile, however, expressed a greater degree of cytotoxicity toward those populations of macrophages induced in vivo with asbestos, than toward any of the other populations of cells. These results are compared with data concerning the enzyme release from the different populations of macrophages following phagocytosis of asbestos. The results indicate that those macrophages that have been exposed to a prior stimulation of either amphibole or serpentine asbestos in vivo are particularly sensitive to exposure to a second dose of a toxic fiber.
摘要
已比较了处于不同激活阶段的小鼠腹腔巨噬细胞对石棉的吞噬作用所产生的体外效应。闪石表现出相对惰性；然而，温石棉对体内由石棉诱导产生的巨噬细胞群体的细胞毒性，比对任何其他细胞群体都更大。将这些结果与关于石棉吞噬后不同巨噬细胞群体酶释放的数据进行了比较。结果表明，那些在体内事先受到闪石或蛇纹石石棉刺激的巨噬细胞，对接触第二剂有毒纤维特别敏感。
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