接受促肾上腺皮质激素（ACTH）治疗的婴儿痉挛症患者脑脊液中同型肌肽水平。

Homocarnosine levels in cerebrospinal fluid of patients with infantile spasms under ACTH therapy.

作者信息

Ohtsuka C, Sato Y, Takahashi H

出版信息

Brain Dev. 1983;5(5):464-8. doi: 10.1016/s0387-7604(83)80075-8.

Abstract

The alteration of homocarnosine (dipeptide of GABA and histidine) levels in cerebrospinal fluid (CSF) was studied on 8 cases with infantile spasms under ACTH therapy. CSF was obtained by lumbar puncture before and during ACTH therapy. Homocarnosine was determined by the amino acid autoanalyzer. The attacks of infantile spasms were well controlled in all 8 cases by ACTH therapy. Homocarnosine levels in cerebrospinal fluid of each case decreased from 1.09 to 0.55, 0.92 to 0.41, 1.23 to 0.90, 0.79 to 0.49, 1.06 to 0.75, 1.06 to 0.89, 0.84 to 0.33 and 2.17 to 0.97 mumol/dl, respectively. The decrease of homocarnosine in CSF were 49.5%, 55.4%, 26.8%, 38.0%, 29.2%, 16.0%, 60.7% and 55.3%, respectively. This finding suggests that the decrease of homocarnosine in CSF may be related to the disappearance of attacks of infantile spasms.

摘要

对8例接受促肾上腺皮质激素（ACTH）治疗的婴儿痉挛症患儿的脑脊液中高肌肽（γ-氨基丁酸和组氨酸的二肽）水平变化进行了研究。在ACTH治疗前及治疗期间通过腰椎穿刺获取脑脊液。采用氨基酸自动分析仪测定高肌肽。8例患儿的婴儿痉挛发作均通过ACTH治疗得到了良好控制。各病例脑脊液中的高肌肽水平分别从1.09降至0.55、从0.92降至0.41、从1.23降至0.90、从0.79降至0.49、从1.06降至0.75、从1.06降至0.89、从0.84降至0.33以及从2.17降至0.97μmol/dl。脑脊液中高肌肽的降低率分别为49.5%、55.4%、26.8%、38.0%、29.2%、16.0%、60.7%和55.3%。这一发现提示脑脊液中高肌肽的降低可能与婴儿痉挛发作的消失有关。