Bailey R B, Woodword A
Mol Gen Genet. 1984;193(3):507-12. doi: 10.1007/BF00382091.
A new mutation has been described which confers resistance to catabolite repression in Saccharomyces cerevisiae. The mutant allele, termed grr-1 for glucose repression-resistant, is characterized by insensitivity to glucose repression for the cytoplasmic enzymes invertase, maltase, and galactokinase, as well as the mitochondrial enzyme cytochrome c oxidase. Hexokinase levels in grr-1 mutants are approximately 3-fold higher than the corresponding activity of the parental strain. Although the grr-1 allele is expressed phenotypically similarly to the hex-1 (hxk-2) and hex-2 mutations described by Entian et al. (1977) and Zimmermann and Scheel (1977) respectively, we have shown genetically and physiologically that grr-1 represents a new class of mutation.
已描述了一种新的突变，该突变赋予酿酒酵母对分解代谢物阻遏的抗性。该突变等位基因，称为grr-1（葡萄糖阻遏抗性），其特征是对细胞质酶转化酶、麦芽糖酶和半乳糖激酶以及线粒体酶细胞色素c氧化酶的葡萄糖阻遏不敏感。grr-1突变体中的己糖激酶水平比亲本菌株的相应活性高约3倍。尽管grr-1等位基因在表型上的表达与Entian等人（1977年）和Zimmermann与Scheel（1977年）分别描述的hex-1（hxk-2）和hex-2突变相似，但我们已通过遗传学和生理学方法表明，grr-1代表一类新的突变。
