患有慢性肉芽肿病的儿童中性粒细胞对B族链球菌的杀菌能力降低。
Diminished bactericidal capacity for group B streptococci of neutrophils from children with chronic granulomatous disease.
作者信息
Stroobant J, Harris M C, Cody C S, Polin R A, Douglas S D
出版信息
Infect Immun. 1983 Feb;39(2):966-9. doi: 10.1128/iai.39.2.966-969.1983.
Abstract
The bactericidal capacity of neutrophils from healthy adults, male children with chronic granulomatous disease, and obligate heterozygote mothers for type Ic group B streptococci was assessed, using a fluorochrome microassay. Neutrophils from patients with chronic granulomatous disease had impaired bactericidal capacity for group B streptococci when compared with adults (P less than 0.01). Carriers demonstrated intermediate killing capacity.
摘要
采用荧光染料微量分析法评估了健康成年人、患有慢性肉芽肿病的男童以及Ic型B族链球菌的 obligate 杂合子母亲的中性粒细胞杀菌能力。与成年人相比，患有慢性肉芽肿病患者的中性粒细胞对B族链球菌的杀菌能力受损（P小于0.01）。携带者表现出中等的杀菌能力。 （注：“obligate heterozygote”直译为“专性杂合子”，在医学语境中可能是特定术语，具体含义需结合更专业背景确定，这里保留英文未准确翻译，因为可能存在专业领域内更准确的译法未知情况）
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