鼠伤寒沙门氏菌中移码突变的新型抑制因子。
New suppressors of frameshift mutations in Salmonella typhimurium.
作者信息
Kohno T, Bossi L, Roth J R
出版信息
Genetics. 1983 Jan;103(1):23-9. doi: 10.1093/genetics/103.1.23.
Abstract
Several new types of suppressor mutants have been isolated. These were identified among revertants of mutants originally generated by mutagens other than the acridine-derived ICR191. The new suppressors correct mutations other than those with runs of C or G which are recognized by the previously described suppressors. Several frameshift mutations are corrected by more than one suppressor type. Apparently, the DNA base sequence near these mutant sites includes sites of action for several distinct suppressor types.
摘要
已经分离出几种新型的抑制突变体。这些突变体是在最初由除吖啶衍生的ICR191以外的诱变剂产生的突变体的回复突变体中鉴定出来的。新的抑制因子能纠正除了那些具有C或G串联的突变以外的其他突变，而这些C或G串联突变是先前描述的抑制因子所识别的。几种移码突变可被不止一种抑制因子类型纠正。显然，这些突变位点附近的DNA碱基序列包括几种不同抑制因子类型的作用位点。
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