Johnson R B, Köhl S, Bessler W G
Infect Immun. 1983 Mar;39(3):1481-4. doi: 10.1128/iai.39.3.1481-1484.1983.
Lipoprotein prepared from the outer membrane of Salmonella typhimurium is a polyclonal activator of murine B-lymphocytes. It was shown to be mitogenic for splenic cultures, stimulating increased incorporation of [3H]thymidine into DNA. When injected intravenously into mice, the lipoprotein induced splenomegaly and polyclonal B-cell activation. The latter was evident from an increase in the number of plaque-forming cells against trinitrophenylated sheep erythrocytes. Similar results were obtained with Escherichia coli lipoprotein.
从鼠伤寒沙门氏菌外膜制备的脂蛋白是小鼠B淋巴细胞的多克隆激活剂。已证明它对脾细胞培养物有促有丝分裂作用,刺激[3H]胸苷掺入DNA增加。当静脉注射到小鼠体内时,该脂蛋白可诱导脾肿大和多克隆B细胞激活。后者可通过针对三硝基苯化绵羊红细胞的噬斑形成细胞数量增加而明显看出。用大肠杆菌脂蛋白也得到了类似的结果。