一种携带控制对细胞内寄生虫抗性的遗传位点（Ityr）的BALB/c同源近交系小鼠。
A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites.
作者信息
Potter M, O'Brien A D, Skamene E, Gros P, Forget A, Kongshavn P A, Wax J S
出版信息
Infect Immun. 1983 Jun;40(3):1234-5. doi: 10.1128/iai.40.3.1234-1235.1983.
Abstract
BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b congenic mice were developed by introgressively backcrossing the Idh-1b and Pep-3b markers of DBA/2 mice onto the BALB/c pi mice. This introduced a 30-centimorgan chromosome 1 segment of DBA/2 chromatin that contained the Ityr gene. BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b mice were resistant to in vivo infections by Salmonella typhimurium, Mycobacterium bovis, and Leishmania donovani.
摘要
通过将DBA/2小鼠的Idh-1b和Pep-3b标记基因渐渗回交至BALB/c品系小鼠，培育出了BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b同源近交系小鼠。这引入了一段包含Ityr基因的30厘摩的1号染色体DBA/2染色质片段。BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b小鼠对鼠伤寒沙门氏菌、牛分枝杆菌和杜氏利什曼原虫的体内感染具有抗性。
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