多发性硬化症患者和正常受试者血清中人类冠状病毒229E和OC43抗体的检测。
Detection of antibodies to human coronaviruses 229E and OC43 in the sera of multiple sclerosis patients and normal subjects.
作者信息
Hovanec D L, Flanagan T D
出版信息
Infect Immun. 1983 Jul;41(1):426-9. doi: 10.1128/iai.41.1.426-429.1983.
Abstract
Sera collected from 90 multiple sclerosis patients and 148 age-matched normal subjects were examined for the presence of antibodies against human coronaviruses (HCV) 229E and OC43 by enzyme immunoassay (EIA). The results demonstrated no significant difference between the MS patients and the normal subjects in their antibody titer to HCV 229E and HCV OC43. Further analysis of these 238 sera indicated that a stronger EIA reaction was generally observed against HCV OC43 (mean EIA value at an optical density of 492 nm = 0.896) than against HCV 229E (mean EIA value at an optical density of 492 nm = 0.346).
摘要
通过酶免疫测定法（EIA）检测了从90例多发性硬化症患者和148例年龄匹配的正常受试者采集的血清中针对人类冠状病毒（HCV）229E和OC43的抗体。结果表明，多发性硬化症患者和正常受试者之间针对HCV 229E和HCV OC43的抗体滴度没有显著差异。对这238份血清的进一步分析表明，一般观察到针对HCV OC43的EIA反应（492nm光密度下的平均EIA值 = 0.896）比对HCV 229E的反应（492nm光密度下的平均EIA值 = 0.346）更强。
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