Wright A D, Bradwell A R, Fletcher R F
Aviat Space Environ Med. 1983 Jul;54(7):619-21.
Methazolamide (150 mg/d) was as effective as acetazolamide (500 mg/d) in preventing the symptoms of acute mountain sickness in 20 subjects ascending to 4985 m. PaO2 and oxygen saturation levels were similar on the two drugs but the fall in PaCO2 was greater on acetazolamide. Paraesthesiae, a side-effect of carbonic anhydrase inhibitors, tended to be less at high altitude on methazolamide and was significantly less when taking 100 mg/d at low altitude. It is likely that paraesthesiae is similar on the two drugs when given in doses that affect blood gases equally.
在20名攀登至4985米高度的受试者中，甲醋唑胺（150毫克/天）预防急性高原病症状的效果与乙酰唑胺（500毫克/天）相当。两种药物治疗时的动脉血氧分压（PaO2）和血氧饱和度水平相似，但乙酰唑胺使动脉血二氧化碳分压（PaCO2）下降幅度更大。碳酸酐酶抑制剂的副作用——感觉异常，在高海拔地区使用甲醋唑胺时往往较轻，在低海拔地区服用100毫克/天时明显减轻。当给予两种药物同等影响血气的剂量时，感觉异常可能相似。
