Manci E A, Heath L S, Leinbach S S, Coggin J H
Am J Pathol. 1984 Jul;116(1):1-8.
In a hamster model of non-Hodgkin's lymphoma which closely parallels the disease in man, and which is induced by an unusual agent(s), a diarrheal bowel disease was a major cause of mortality. This study was initiated to characterize this bowel disease and its relation to lymphoma induction and to natural diseases seen in the hamster. The studies showed that the bowel disease was an ulcerative process and was distinct from natural diseases. The incidence of the bowel disease correlated directly with that of the lymphoma in repeated epizootics, in titration studies, and in agent inactivation tests. The ulcerative bowel lesions were seen at the same stage of the disease as acute and chronic inflammatory infiltrates with necrosis in the thymus and mesenteric lymph nodes. Since necrosis in the gut-associated lymphoid tissue can lead to perforation and sepsis, these bowel lesions were lethal, whereas similar necrosis in other lymphoid tissues (thymus and lymph nodes) could be clinically undetectable. Similar lesions have been reported in man. The ulcerative bowel disease was a reliable early clinical marker for exposure of hamsters to this lymphomagenic agent(s).
在一种与人类疾病极为相似的非霍奇金淋巴瘤仓鼠模型中，该模型由一种特殊因子诱发，腹泻性肠道疾病是主要的死亡原因。开展本研究旨在明确这种肠道疾病的特征、其与淋巴瘤诱发的关系以及仓鼠中所见的自然疾病。研究表明，肠道疾病是一个溃疡性过程，且与自然疾病不同。在重复的动物流行病史、滴定研究及因子灭活试验中，肠道疾病的发病率与淋巴瘤的发病率直接相关。溃疡性肠道病变与胸腺和肠系膜淋巴结中伴有坏死的急性和慢性炎性浸润处于疾病的同一阶段。由于肠道相关淋巴组织中的坏死可导致穿孔和败血症，这些肠道病变是致命的，而其他淋巴组织（胸腺和淋巴结）中类似的坏死在临床上可能无法检测到。人类中也有类似病变的报道。溃疡性肠道疾病是仓鼠接触这种致淋巴瘤因子的可靠早期临床标志物。
