Pahwa S G, Quilop M T, Lange M, Pahwa R N, Grieco M H
Ann Intern Med. 1984 Dec;101(6):757-63. doi: 10.7326/0003-4819-101-6-757.
Patients with the acquired immunodeficiency syndrome manifest a wide spectrum of immunologic abnormalities. Polyclonal and antigen-specific differentiation of B lymphocytes into immunoglobulin- and antibody-secreting cells was studied in vitro in three groups of homosexual volunteers: asymptomatic men; men who were symptomatic but lacked clinical criteria for the acquired immunodeficiency syndrome; and those having the syndrome. Although mean responses of all three groups were significantly lower than those of healthy heterosexual male controls, those of the asymptomatic group were least affected. Abnormalities in the symptomatic group were equal to or greater than those of patients with the syndrome, but responses of the latter group were the least augmentable by in vitro manipulations. Severe impairment of B-cell function appeared to favor clinical deterioration. Antibody replenishment might be of value as adjunctive therapy in persons with the acquired immunodeficiency syndrome or as prophylaxis in certain at-risk persons.
获得性免疫缺陷综合征患者表现出广泛的免疫异常。在三组同性恋志愿者中对B淋巴细胞向免疫球蛋白分泌细胞和抗体分泌细胞的多克隆及抗原特异性分化进行了体外研究：无症状男性；有症状但缺乏获得性免疫缺陷综合征临床标准的男性；以及患有该综合征的男性。尽管所有三组的平均反应均显著低于健康异性恋男性对照组，但无症状组受影响最小。有症状组的异常情况与患有该综合征的患者相当或更严重，但后一组的反应在体外操作下最不易增强。B细胞功能的严重受损似乎有利于临床病情恶化。抗体补充作为获得性免疫缺陷综合征患者的辅助治疗或某些高危人群的预防措施可能具有价值。
