Kinship mapping of multilocus systems.

The linear order of loci in a complex system can be determined by recombination, physical assignment, and correspondence of rare haplotypes with double recombinants. An independent approach is based on the concept of kinship between pairs of loci which gives the apparently correct order for the Rhesus system. Noise due to drift, selection, recent hybridization, and errors of haplotype frequency estimation can be controlled by averaging over populations.