落基山斑疹热疫苗在动物模型中的研究
Rocky Mountain spotted fever vaccine in an animal model.
作者信息
Folds J D, Walker D H, Hegarty B C, Banasiak D, Lange J V
出版信息
J Clin Microbiol. 1983 Aug;18(2):321-6. doi: 10.1128/jcm.18.2.321-326.1983.
Formalin-killed, purified Rickettsia rickettsii vaccine was evaluated in a guinea pig model of R. rickettsii infection. Vaccinated guinea pigs were partially protected by the vaccine when challenged with virulent, viable rickettsiae. Greater protection was observed when higher doses of vaccine were given and when frequent booster injections were administered. Stimulation of cell-mediated immunity to the vaccine antigens was variable and also appeared to be achieved more reproducibly with booster vaccinations. Serum antibody was elicited by high doses of vaccine and by booster vaccinations. The presence of serum antibody was useful in predicting immunity to challenge with R. rickettsii.
在立氏立克次体感染的豚鼠模型中评估了福尔马林灭活的纯化立氏立克次体疫苗。用强毒、活的立克次体攻击时，接种疫苗的豚鼠受到该疫苗的部分保护。当给予更高剂量的疫苗以及进行频繁的加强注射时，观察到了更强的保护作用。对疫苗抗原的细胞介导免疫刺激存在差异，并且似乎通过加强接种能更可重复地实现。高剂量疫苗和加强接种可诱导血清抗体产生。血清抗体的存在有助于预测对立氏立克次体攻击的免疫力。
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