美国皮肤利什曼病中抗层粘连蛋白抗体
Antibodies to laminin in American cutaneous leishmaniasis.
作者信息
Avila J L, Rojas M, Rieber M
出版信息
Infect Immun. 1984 Jan;43(1):402-6. doi: 10.1128/iai.43.1.402-406.1984.
Abstract
We found that serum samples from patients with different clinical forms of American cutaneous leishmaniasis (ACL) contained immunoglobulin G and immunoglobulin M antibodies which reacted with laminin but not with various other purified connective tissue components, such as collagen types I, III, IV, and V and fibronectin. Eighty-one percent of ACL patients had high antilaminin antibody levels, with a relationship existing between ACL ulcers and antibody levels. This was not, however, the case with patients having treated and healed ACL ulcers; only 34% of these patients had elevated antilaminin antibodies. Eighty-four percent of chronic Chagas' disease patients were also found to contain antilaminin antibodies that were limited to the immunoglobulin G class, but these were not detected in patients suffering from any of 11 other infectious diseases.
摘要
我们发现，来自患有不同临床形式的美洲皮肤利什曼病（ACL）患者的血清样本中含有免疫球蛋白G和免疫球蛋白M抗体，这些抗体与层粘连蛋白发生反应，但不与其他各种纯化的结缔组织成分发生反应，如I型、III型、IV型和V型胶原蛋白以及纤连蛋白。81%的ACL患者抗层粘连蛋白抗体水平较高，ACL溃疡与抗体水平之间存在关联。然而，对于已治疗并愈合的ACL溃疡患者则并非如此；这些患者中只有34%的抗层粘连蛋白抗体升高。还发现84%的慢性恰加斯病患者也含有仅限于免疫球蛋白G类的抗层粘连蛋白抗体，但在患有其他11种传染病中的任何一种的患者中均未检测到这些抗体。
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