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三个易位阴性小鼠浆细胞瘤中15号染色体（D带）的半合子间质性缺失

Hemizygous interstitial deletion of chromosome 15 (band D) in three translocation-negative murine plasmacytomas.

作者信息

Wiener F, Ohno S, Babonits M, Sümegi J, Wirschubsky Z, Klein G, Mushinski J F, Potter M

出版信息

Proc Natl Acad Sci U S A. 1984 Feb;81(4):1159-63. doi: 10.1073/pnas.81.4.1159.

DOI:10.1073/pnas.81.4.1159
PMID:6422467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC344785/
Abstract

Three murine plasmacytomas that were exceptional in lacking the characteristic (12;15) or (6;15) translocations were studied by G banding and high-resolution banding. One of every two chromosomes 15 (two of four in tetraploid tumors) was shortened in all three tumors. High-resolution banding analysis revealed that this was due to an interstitial deletion in the 15D band region. The two breaks responsible for the deletion have been tentatively localized to the interface of bands D2/3' and within band D2. One of the three plasmacytomas, ABPC45, had a rearranged c-myc gene. All three tumors contained a greater abundance of 2.4-kilobase myc RNA transcripts than normal spleen or thymus. The c-myc gene is located in the 15 D2/3 band region. We suggest that it may have joined the centromeric portion in the deletion plasmacytomas. This transposition may have led to its constitutive activation, as in the more frequent translocation-carrying plasmacytomas.

摘要

对三例缺乏特征性（12；15）或（6；15）易位的小鼠浆细胞瘤进行了G显带和高分辨显带研究。在所有三例肿瘤中，每两条15号染色体中的一条（四倍体肿瘤中的四条中的两条）都缩短了。高分辨显带分析表明，这是由于15D带区的中间缺失所致。导致缺失的两个断点初步定位于D2/3'带的界面和D2带内。三例浆细胞瘤之一ABPC45，其c-myc基因发生了重排。所有三例肿瘤中2.4千碱基的myc RNA转录本含量均高于正常脾脏或胸腺。c-myc基因位于15 D2/3带区。我们认为它可能在缺失型浆细胞瘤中与着丝粒部分相连。这种转位可能导致了它的组成型激活，就像在更常见的携带易位的浆细胞瘤中一样。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/6dfc0abdfb46/pnas00605-0186-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/d1e6771a1478/pnas00605-0184-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/1c59c4398402/pnas00605-0185-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/070ffb6290e5/pnas00605-0186-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/0fee4c6a532e/pnas00605-0186-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/efff73942580/pnas00605-0186-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/0d824f0104cd/pnas00605-0186-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/3f1b5d1f8a21/pnas00605-0186-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/6dfc0abdfb46/pnas00605-0186-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/d1e6771a1478/pnas00605-0184-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/1c59c4398402/pnas00605-0185-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/070ffb6290e5/pnas00605-0186-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/0fee4c6a532e/pnas00605-0186-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/efff73942580/pnas00605-0186-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/0d824f0104cd/pnas00605-0186-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/3f1b5d1f8a21/pnas00605-0186-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b117/344785/6dfc0abdfb46/pnas00605-0186-f.jpg

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