重度破伤风患者的高肾上腺素能综合征：儿茶酚胺极度升高且对拉贝洛尔有反应。

Hyperadrenergic syndrome in severe tetanus: extreme rise in catecholamines responsive to labetalol.

作者信息

Domenighetti G M, Savary G, Stricker H

出版信息

Br Med J (Clin Res Ed). 1984 May 19;288(6429):1483-4. doi: 10.1136/bmj.288.6429.1483.

DOI:10.1136/bmj.288.6429.1483

PMID:6426611

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1441180/

Abstract

The hyperadrenergic syndrome that occurs in tetanus is characterised by hypertension, tachycardia, and increased systemic arteriolar resistance. A 74 year old man with tetanus was found to have very high catecholamine concentrations--as high as those in phaeochromocytoma--and the fluctuations in blood pressure and heart rate were measured to see whether they paralleled changes in the catecholamine values. A labetalol infusion of 0.25-1 mg/min gradually stabilised the cardiovascular disturbances and the patient recovered.

摘要

破伤风时发生的高肾上腺素能综合征的特征为高血压、心动过速和全身小动脉阻力增加。一名74岁破伤风患者被发现儿茶酚胺浓度极高——与嗜铬细胞瘤患者的浓度一样高——并对其血压和心率波动进行了测量，以观察它们是否与儿茶酚胺值的变化平行。以0.25 - 1毫克/分钟的速度输注拉贝洛尔逐渐稳定了心血管紊乱，患者康复。