Fleurette J, Ritter J
Ann Microbiol (Paris). 1980 Sep-Oct;131B(2):175-83.
Prevalence of exfoliatin production has been investigated in 100 strains of Staphylococcus aureus, bacteriophage group II, by inoculation into newborn mice. Serotyping, detection of protein A and antibiotic susceptibility tests have also been performed. Thirty-one strains (31%) were toxin producers; they all produced a yellow pigment; there was no difference in phage attacks between toxinogenic and non-toxinogenic strains; but exfoliatin production was significantly associated to the presence of agglutinogens h2 and 263-2; rate of protein-A presence and of antibiotic susceptibility did not differ between the two groups of strains. In addition, toxin production has been investigated in 31 isolates from various skin lesions; 9 were found toxinogenic (8 amongst them had been cultivated from bullous lesions); most of them belonged to phage group II and possessed agglutinogens h2 and 263-2. So, in order to carry out the diagnosis of some bacterial skin infections, clinical symptoms, pathological and bacteriological data must be compared; the latter must include phage-typing, serotyping and exfoliatin detection.
通过接种新生小鼠,对100株II组噬菌体金黄色葡萄球菌的表皮剥脱毒素产生情况进行了研究。还进行了血清分型、蛋白A检测和药敏试验。31株(31%)为毒素产生菌;它们均产生黄色色素;产毒菌株和不产毒菌株在噬菌体攻击方面无差异;但表皮剥脱毒素的产生与凝集原h2和263-2的存在显著相关;两组菌株中蛋白A的存在率和药敏率无差异。此外,对从各种皮肤病变中分离出的31株菌株进行了毒素产生情况的研究;发现9株产毒(其中8株从大疱性病变中培养获得);它们大多属于II组噬菌体,且具有凝集原h2和263-2。因此,为了对某些细菌性皮肤感染进行诊断,必须比较临床症状、病理和细菌学数据;后者必须包括噬菌体分型、血清分型和表皮剥脱毒素检测。