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传染性单核细胞增多症患者外周血中具有抑制性T细胞表型的细胞数量增加。

Increased numbers of cells with suppressor T cell phenotype in the peripheral blood of patients with infectious mononucleosis.

作者信息

Crawford D H, Brickell P, Tidman N, McConnell I, Hoffbrand A V, Janossy G

出版信息

Clin Exp Immunol. 1981 Feb;43(2):291-7.

PMID:6456093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537280/
Abstract

Peripheral blood cells from six patients with acute infectious mononucleosis were studied by two-colour immunofluorescence using antibodies to human T cells, inducer and suppressor-cytotoxic T cell subsets and Ia-like antigens. The absolute number of T cells with the suppressor-cytotoxic phenotype was substantially increased in each case; many of these cells also expressed Ia-like antigens and had the morphology of the large atypical cells characteristic of infectious mononucleosis. These activated suppressor T cells of infectious mononucleosis may therefore represent a control mechanism to prevent viral-induced proliferation of B cells.

摘要

采用针对人T细胞、诱导性及抑制性-细胞毒性T细胞亚群以及Ia样抗原的抗体，通过双色免疫荧光法对6例急性传染性单核细胞增多症患者的外周血细胞进行了研究。在每例患者中，具有抑制性-细胞毒性表型的T细胞绝对数量均显著增加；其中许多细胞还表达Ia样抗原，并且具有传染性单核细胞增多症特征性的大的非典型细胞形态。因此，传染性单核细胞增多症的这些活化抑制性T细胞可能代表一种控制机制，以防止病毒诱导的B细胞增殖。

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Increased numbers of cells with suppressor T cell phenotype in the peripheral blood of patients with infectious mononucleosis.传染性单核细胞增多症患者外周血中具有抑制性T细胞表型的细胞数量增加。
Clin Exp Immunol. 1981 Feb;43(2):291-7.
2
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Suppressor T cell clones from patients with acute Epstein-Barr virus-induced infectious mononucleosis.来自急性爱泼斯坦-巴尔病毒引起的传染性单核细胞增多症患者的抑制性T细胞克隆。
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Factors that influence activated CD8+ T-cell apoptosis in patients with acute herpesvirus infections: loss of costimulatory molecules CD28, CD5 and CD6 but relative maintenance of Bax and Bcl-X expression.影响急性疱疹病毒感染患者活化CD8 + T细胞凋亡的因素：共刺激分子CD28、CD5和CD6缺失，但Bax和Bcl-X表达相对维持。
Immunology. 1996 Aug;88(4):508-15.
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T cell regeneration after allogeneic bone marrow transplantation.异基因骨髓移植后的T细胞再生
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Immunological studies of autoimmune thyroid disorders: abnormalities in the inducer T cell subset and proliferative responses to autologous and allogeneic stimulation.自身免疫性甲状腺疾病的免疫学研究：诱导性T细胞亚群异常以及对自身和同种异体刺激的增殖反应。
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本文引用的文献

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Peripheral blood Ia-positive T cells. Increases in certain diseases and after immunization.外周血Ia阳性T细胞。在某些疾病及免疫后数量增加。
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Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage.人类胸腺内分化的离散阶段：T细胞系正常胸腺细胞和白血病淋巴母细胞的分析
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1588-92. doi: 10.1073/pnas.77.3.1588.
3
A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2.一种单克隆抗体，可与人细胞毒性/抑制性T细胞亚群发生反应，该亚群先前由一种名为TH2的异种抗血清所定义。
J Immunol. 1980 Mar;124(3):1301-7.
4
Long-term T-cell-mediated immunity to Epstein-Barr virus in man. IV. Development of T-cell memory in convalescent infectious mononucleosis patients.人类对EB病毒的长期T细胞介导免疫。IV. 恢复期传染性单核细胞增多症患者T细胞记忆的发展。
Int J Cancer. 1980 Jan 15;25(1):59-65. doi: 10.1002/ijc.2910250108.
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Diffuse polyclonal B-cell lymphoma during primary infection with Epstein-Barr virus.初次感染爱泼斯坦-巴尔病毒期间的弥漫性多克隆B细胞淋巴瘤
N Engl J Med. 1980 Jun 5;302(23):1293-7. doi: 10.1056/NEJM198006053022306.
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The glomerular permeability determined by dextran clearance using Sephadex gel filtration.通过使用葡聚糖凝胶过滤法测定葡聚糖清除率来确定肾小球通透性。
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The atypical lymphocyte.异型淋巴细胞。
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Relation of Burkitt's tumor-associated herpes-ytpe virus to infectious mononucleosis.伯基特淋巴瘤相关疱疹病毒与传染性单核细胞增多症的关系。
Proc Natl Acad Sci U S A. 1968 Jan;59(1):94-101. doi: 10.1073/pnas.59.1.94.
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Demonstration of a herpes group virus in cultures of peripheral leukocytes from patients with infectious mononucleosis.在传染性单核细胞增多症患者外周血白细胞培养物中证实有疱疹病毒群病毒。
J Virol. 1968 Jul;2(7):663-9. doi: 10.1128/JVI.2.7.663-669.1968.
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T- and B-cells in peripheral blood during infectious mononucleosis.
J Infect Dis. 1974 Aug;130(2):104-11. doi: 10.1093/infdis/130.2.104.