Caramaschi F, del Corno G, Favaretti C, Giambelluca S E, Montesarchio E, Fara G M
Int J Epidemiol. 1981 Jun;10(2):135-43. doi: 10.1093/ije/10.2.135.
Data are presented on the occurrence of chloracne, clinical symptoms and biochemical changes in 164 children following environmental contamination by TCDD from an industrial accident in Seveso, Italy. An overall positive association was found between the territorial distribution of chloracne cases and the different levels of soil contamination in the affected area. Individual risk factors such as condition and length of exposure, intake via contaminated foods, etc. were evaluated; no single factor appeared to be associated with chloracne. Disturbances of the gastrointestinal tract were more frequently observed in children affected with chloracne in those from the same areas having no skin lesions. However, no clinically definable systemic disease has been diagnosed.
本文呈现了意大利塞韦索一场工业事故导致二噁英环境污染后，164名儿童发生氯痤疮、临床症状及生化变化的数据。氯痤疮病例的地域分布与受影响地区不同程度的土壤污染之间存在总体正相关。对个体风险因素如接触状况和时长、通过受污染食物的摄入量等进行了评估；没有单一因素似乎与氯痤疮相关。在同一地区有氯痤疮的儿童中，胃肠道紊乱比无皮肤病变的儿童更常见。然而，尚未诊断出临床上可明确的全身性疾病。
