Thomas J B, Bastiani M J, Bate M, Goodman C S
Nature. 1984;310(5974):203-7. doi: 10.1038/310203a0.
Little is known about the mechanisms that generate neuronal specificity during development. Whereas the grasshopper embryo has been an ideal system for a cellular analysis of neuronal development, the Drosophila embryo has obvious attributes for a molecular genetic analysis. Here we show that the early Drosophila embryo is a miniature replica of the grasshopper embryo in terms of its identified neurones, their growth cones and their selective fasciculation choices, thus opening the way for a combined cellular and molecular genetic analysis of cell recognition during neuronal development in Drosophila.
关于发育过程中产生神经元特异性的机制，人们了解甚少。虽然蚱蜢胚胎一直是进行神经元发育细胞分析的理想系统，但果蝇胚胎在分子遗传学分析方面具有明显优势。我们在此表明，就其已识别的神经元、它们的生长锥以及它们的选择性成束选择而言，早期果蝇胚胎是蚱蜢胚胎的一个微型复制品，从而为果蝇神经元发育过程中细胞识别的细胞和分子遗传学联合分析开辟了道路。
