用降解角叉菜胶诱导大鼠结肠肿瘤
Induction by degraded carrageenan of colorectal tumors in rats.
作者信息
Ashi K W, Inagaki T, Fujimoto Y, Fukuda Y
出版信息
Cancer Lett. 1978 Mar;4(3):171-6. doi: 10.1016/s0304-3835(78)94237-4.
PMID:647659
Abstract
Degraded carrageenan derived from the red seaweed Eucheuma spinosum was given to Sprague-Dawley rats through the diet, in drinking water or by stomach tube for up to 24 months. Carrageenan-induced squamous cell carcinomas, adenocarcinomas and adenomas in the colorectum were observed. Some rats had metastases to the regional lymph nodes of squamous cell carcinomas. These results show that degraded carrageenan is carcinogenic to the colorectum of the rat.
摘要
将源自红藻刺麒麟菜的降解卡拉胶通过饮食、饮用水或胃管给予斯普拉格-道利大鼠，持续24个月。观察到卡拉胶诱发大鼠结肠直肠出现鳞状细胞癌、腺癌和腺瘤。一些大鼠的鳞状细胞癌转移至区域淋巴结。这些结果表明，降解卡拉胶对大鼠结肠直肠具有致癌性。
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