低密度脂蛋白受体阴性的培养人成纤维细胞对外源性胆固醇的摄取和酯化作用
Uptake and esterification of exogenous cholesterol by low-density-lipoprotein-receptor-negative human fibroblasts in culture.
作者信息
Slotte J P, Ekman S, Björkerud S
出版信息
Biochem J. 1984 Sep 15;222(3):821-4. doi: 10.1042/bj2220821.
Abstract
The incorporation and metabolism of both vesicle- and LDL (low-density lipoprotein)- derived [3H]cholesterol by LDL-receptor-negative fibroblasts were studied. Independent of the cholesterol source, free [3H]cholesterol was readily incorporated into the cells and was available for esterification. 7-Oxocholesterol stimulated both [3H]cholesterol incorporation, by increasing the exchange rate, and the subsequent esterification of it irrespective of the source of exogenous [3H]cholesterol. The 7-oxocholesterol-stimulated esterification of exogenously derived LDL free [3H]cholesterol was progesterone-sensitive and energy-requiring.
摘要
研究了低密度脂蛋白受体阴性成纤维细胞对囊泡和低密度脂蛋白（LDL）衍生的[3H]胆固醇的摄取和代谢。与胆固醇来源无关，游离[3H]胆固醇很容易被细胞摄取并可用于酯化。7-氧胆固醇通过提高交换率刺激[3H]胆固醇的摄取以及随后的酯化，而与外源性[3H]胆固醇的来源无关。7-氧胆固醇刺激的外源性LDL游离[3H]胆固醇的酯化对孕酮敏感且需要能量。
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本文引用的文献
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