过量产生天冬酰胺基 - tRNA合成酶的中国仓鼠卵巢细胞的分离。
Isolation of Chinese hamster ovary cells that overproduce asparaginyl-tRNA synthetase.
作者信息
Cirullo R E, Wasmuth J J
出版信息
Mol Cell Biol. 1984 Sep;4(9):1939-41. doi: 10.1128/mcb.4.9.1939-1941.1984.
Abstract
Temperature-resistant revertants, derived from the temperature-sensitive CHO asparaginyl-tRNA synthetase mutant, Asn-5, were isolated and characterized. Several lines of evidence indicate that the temperature-resistant phenotype of the revertants is due to their overproducing the same altered enzyme present in the Asn-5 parent.
摘要
从温度敏感型中国仓鼠天冬酰胺-tRNA合成酶突变体Asn-5衍生而来的耐温回复突变体被分离并进行了特性分析。多条证据表明，回复突变体的耐温表型是由于它们过量产生了Asn-5亲本中存在的相同的改变型酶。
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