脑脊液的凝血和纤溶活性。
Coagulation and fibrinolytic activity of cerebrospinal fluid.
作者信息
Anderson M, Matthews K B, Stuart J
出版信息
J Clin Pathol. 1978 May;31(5):488-92. doi: 10.1136/jcp.31.5.488.
Abstract
Fibrin/fibrinogen degradation products (fragments D and E) were detected in cerebrospinal fluid in 23.4% of 252 patients admitted to a neurological/neurosurgical unit. Other coagulation proteins of low molecular weight (plasminogen and factor IX) were also present but larger proteins (fibrinogen and factor V) were not. These findings are consistent with protein leakage across a blood-CSF barrier damaged by inflammatory, vascular, or neoplastic disease. Fibrin/fibrinogen degradation products in cerebrospinal fluid after subarachnoid haemorrhage may not, therefore, be a reliable index of increased fibrinolytic activity in the subarachnoid space and may be misleading when selecting patients for fibrinolytic blockade.
摘要
在一所神经科/神经外科收治的252例患者中，23.4%的患者脑脊液中检测到纤维蛋白/纤维蛋白原降解产物（D片段和E片段）。其他低分子量凝血蛋白（纤溶酶原和因子IX）也存在，但较大的蛋白（纤维蛋白原和因子V）不存在。这些发现与炎症、血管或肿瘤性疾病破坏血脑屏障后蛋白质渗漏一致。因此，蛛网膜下腔出血后脑脊液中的纤维蛋白/纤维蛋白原降解产物可能不是蛛网膜下腔纤溶活性增加的可靠指标，在选择进行纤溶阻断治疗的患者时可能会产生误导。
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