N10-甲基叶酸对人白细胞中高亲和力叶酸结合的定量和定性影响。
Quantitative and qualitative effects of N10-methylfolate on high-affinity folate binding in human leukocytes.
作者信息
Holm J, Hansen S I, Lyngbye J
出版信息
Int J Vitam Nutr Res. 1984;54(2-3):195-7.
PMID:6500843
Abstract
N10-methylfolate acted as a potent competitive inhibitor of high-affinity [3H] folate binding in human leukocytes, while methotrexate had no effect. Furthermore, folate binding changed into a non-cooperative type in the presence of N10-methylfolate. Hence, in qualitative and quantitative respects, the substrate specificity characteristics of leukocyte folate binding resemble those of other high-affinity folate binding systems.
摘要
N10-甲基叶酸是人类白细胞中高亲和力[3H]叶酸结合的有效竞争性抑制剂，而甲氨蝶呤则无此作用。此外，在N10-甲基叶酸存在的情况下，叶酸结合转变为非协同类型。因此，在定性和定量方面，白细胞叶酸结合的底物特异性特征与其他高亲和力叶酸结合系统相似。
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