氨基酸——仓鼠黑色素瘤中黑色素合成的前体。
Aminoacids--precursors of melanin synthesis in hamster melanoma.
作者信息
Blagoeva P M
出版信息
J Cancer Res Clin Oncol. 1984;108(3):366-8. doi: 10.1007/BF00390476.
Abstract
The role of L-tyrosine, L-phenylalanine, L-dihydroxyphenylalanine (dopa) and L-tryptophan in melanin biosynthesis in melanotic hamster melanoma IC-Sofia was investigated with the aid of 14C-aminoacids. Tyrosine and phenylalanine were found to be the main melanin precursors: about 64.5% of total melanin labeling was due to tyrosine incorporation and 27.4% to phenylalanine incorporation. Negligible proportions of melanin radioactivity (5.7% and 2.4%, respectively) resulted from dopa and tryptophan utilization in melanin synthesis. The involvement of each of the aminoacids under investigation in melanin synthesis in vivo is discussed.
摘要
借助14C-氨基酸研究了L-酪氨酸、L-苯丙氨酸、L-二羟基苯丙氨酸（多巴）和L-色氨酸在黑素瘤仓鼠黑色素瘤IC-索菲亚中黑色素生物合成中的作用。发现酪氨酸和苯丙氨酸是主要的黑色素前体：总黑色素标记的约64.5%归因于酪氨酸掺入，27.4%归因于苯丙氨酸掺入。黑色素合成中多巴和色氨酸利用产生的黑色素放射性比例可忽略不计（分别为5.7%和2.4%）。讨论了所研究的每种氨基酸在体内黑色素合成中的参与情况。
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