各种低分子量酶抑制剂对营养不良小鼠酶网络的类似作用。
Similar effects of various low-molecular-weight enzyme inhibitors on enzyme networks in dystrophic mice.
作者信息
Aoyagi T, Wada T, Ohuchi S, Kojima F, Nagai M, Harada S, Umezawa H
出版信息
J Pharmacobiodyn. 1984 Sep;7(9):681-7. doi: 10.1248/bpb1978.7.681.
We compared the therapeutic effects of various low-molecular-weight enzyme inhibitors on dystrophic mice. Leupeptin, bestatin, forphenicinol and forphenicine significantly affected the enzymatic activities in the dystrophic muscles. The pattern of enzymatic changes in the muscles of forelimb and hindlimb caused by these inhibitors were similar in spite of the variety of their inhibitory spectra in vitro. However, comparing the pattern of enzymatic changes in spleen, forphenicinol differed from the other inhibitors tested. This may be related to the peculiar effects of this inhibitor on immunologically responsive cells.
我们比较了各种低分子量酶抑制剂对营养不良小鼠的治疗效果。亮抑蛋白酶肽、抑氨肽酶素、磷酰胺菌素和磷酰胺酶对营养不良肌肉中的酶活性有显著影响。尽管这些抑制剂在体外具有不同的抑制谱，但它们引起的前肢和后肢肌肉中酶变化的模式相似。然而，比较脾脏中酶变化的模式时，磷酰胺菌素与其他测试抑制剂不同。这可能与该抑制剂对免疫反应细胞的特殊作用有关。
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