Gibbs M E, Ng K T
Pharmacol Biochem Behav. 1978 Mar;8(3):271-6. doi: 10.1016/0091-3057(78)90315-5.
The three-phase model of memory formation in young chicks proposed by Gibbs and Ng [7] was based on a single trial passive avoidance task. Some methodological and interpretative problems associated with this task are not encountered in appetitive visual discrimination tasks. Using such a task, it is shown that 2 mM KCl induces amnesia at 10 min, ouabain at 30 min and cycloheximide at 60 min after learning. These findings are consistent with those for the single trail passive avoidance task and confirm the generality of a model of memory formation in young chicks entailing a short-term phase, a sodium pumo-dependent labile phase, and a long-term, protein synthesis-dependent phase.
吉布斯和吴[7]提出的幼雏记忆形成三相模型基于单次试验被动回避任务。在味觉视觉辨别任务中不会遇到与此任务相关的一些方法和解释问题。使用这样的任务表明,学习后10分钟时2 mM氯化钾会导致失忆,30分钟时哇巴因会导致失忆,60分钟时环己酰亚胺会导致失忆。这些发现与单次试验被动回避任务的发现一致,并证实了幼雏记忆形成模型的普遍性,该模型包括一个短期阶段、一个依赖钠泵的不稳定阶段和一个长期的、依赖蛋白质合成的阶段。