用于重症肌无力抗体检测的新抗原。
New antigen for antibody detection in myasthenia gravis.
作者信息
Gotti C, Mantegazza R, Clementi F
出版信息
Neurology. 1984 Mar;34(3):374-7. doi: 10.1212/wnl.34.3.374.
We assayed anti-acetylcholine receptor (AChR) antibodies in 61 myasthenic patients using human and fetal calf muscle AChR as antigen. Anti-AChR antibodies were detected in 85% of patients with human AChR and in 80% with fetal calf AChR. In 27 patients, the titers detected with fetal calf AChR were higher than those obtained with human AChR. Titers with different fetal calf AChR preparations were reproducible. Fetal calf AChR is a suitable antigen for immunologic analysis of myasthenic patients.
我们以人及胎牛肌肉乙酰胆碱受体（AChR）作为抗原，对61例重症肌无力患者检测了抗乙酰胆碱受体抗体。用人AChR检测时，85%的患者检测到抗AChR抗体；用胎牛AChR检测时，80%的患者检测到该抗体。在27例患者中，用胎牛AChR检测到的抗体滴度高于用人AChR检测到的滴度。不同胎牛AChR制剂检测到的滴度具有可重复性。胎牛AChR是用于重症肌无力患者免疫学分析的合适抗原。
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