一种新型正性肌力药物3,4-二氢-6-[4-(3,4-二甲氧基苯甲酰基)-1-哌嗪基]-2(1H)-喹啉酮(OPC-8212)及其溶剂环丁砜对大鼠、豚鼠和犬离体心脏标本的影响。
Effects of a new positive inotropic agent, 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (OPC-8212) and its solvent sulfolane on isolated heart preparations of the rat, guinea pig, and dog.
作者信息
Grupp G, Grupp I L, Newman G, Schwartz A
出版信息
Arzneimittelforschung. 1984;34(3A):359-63.
3,4-Dihydro-6-[4-(3,4- dimethoxybenzoyl )-1-piperazinyl]-2(1H)- qu inolinone ( OPC -8212) has positive inotropic effects in guinea pig and dog isolated heart preparations. The rat heart ventricle does not respond to OPC -8212 but the atria do. OPC -8212 produces positive inotropic effects in the rat heart ventricle made hypodynamic by pretreatment with calcium entry blockers. Sulfolane , the solvent of OPC -8212, produced negative inotropic effects in most preparations. In isolated heart preparations of the rat and guinea pig, OPC -8212 produced increased coronary flow; sulfolane had only minor effects.
3,4-二氢-6-[4-(3,4-二甲氧基苯甲酰基)-1-哌嗪基]-2(1H)-喹啉酮（OPC-8212）对豚鼠和犬的离体心脏标本有正性肌力作用。大鼠心室对OPC-8212无反应，但心房有反应。OPC-8212对用钙通道阻滞剂预处理后功能减退的大鼠心室有正性肌力作用。OPC-8212的溶剂环丁砜在大多数标本中产生负性肌力作用。在大鼠和豚鼠的离体心脏标本中，OPC-8212使冠脉血流量增加；环丁砜只有轻微作用。
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