采用计算机化气相色谱-质谱联用技术检测尿液中抗抑郁药及其代谢物的筛查程序。
Screening procedure for detection of antidepressants and their metabolites in urine using a computerized gas chromatographic--mass spectrometric technique.
作者信息
Maurer H, Pfleger K
出版信息
J Chromatogr. 1984 Feb 10;305(2):309-23. doi: 10.1016/s0378-4347(00)83345-9.
A method for the identification of antidepressants and their metabolites in urine after acid hydrolysis is described. The acetylated extract is analysed by computerized gas chromatography--mass spectrometry. An on-line computer allows rapid detection using mass fragmentography with the masses 58, 84, 86, 100, 191, 193, 194, 205. The identity of positive signals in the reconstructed mass fragmentogram is established by a comparison of the entire mass spectra with those of standards. The mass fragmentogram, the underlying mass spectra and the gas chromatographic retention indices (OV-101) are documented.
本文描述了一种在酸水解后鉴定尿液中抗抑郁药及其代谢物的方法。乙酰化提取物通过计算机化气相色谱 - 质谱联用仪进行分析。在线计算机通过质量碎片分析法，利用58、84、86、100、191、193、194、205这些质量数实现快速检测。通过将重建质量碎片图中的阳性信号的完整质谱与标准品的质谱进行比较，来确定其身份。记录质量碎片图、基础质谱以及气相色谱保留指数（OV - 101）。
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