Epstein M
Undersea Biomed Res. 1984 Jun;11(2):113-21.
Studies from this laboratory have demonstrated that head-out immersion in isothermic water causes a cephalad redistribution of blood volume. The resultant central hypervolemia induces a marked natriuresis and diuresis and suppression of plasma renin activity, plasma aldosterone, and plasma arginine vasopressin. All of these changes are thought to be attributable to stimulation of cardiopulmonary receptors. Immersion also produces an augmentation of prostaglandin E (PGE) excretion, which reflects increased renal PGE synthesis. The ability of immersion in induce a prompt and profound central hypervolemia, without concomitant alterations in plasma composition, indicates that immersion might be a preferred investigative tool for assessing the effects of volume expansion on renal function and hormonal responsiveness in both normal individuals and patients with edematous disorders. In addition, this model constitutes an appropriate tool for simulating weightlessness.
本实验室的研究表明，头露出水面浸泡在等温水中会导致血容量向头部重新分布。由此产生的中心血容量过多会引发显著的利钠和利尿作用，并抑制血浆肾素活性、血浆醛固酮和血浆精氨酸加压素。所有这些变化都被认为归因于心肺感受器的刺激。浸泡还会导致前列腺素E（PGE）排泄增加，这反映了肾脏PGE合成增加。浸泡能够迅速且显著地引起中心血容量过多，而血浆成分无相应改变，这表明浸泡可能是评估容量扩张对正常个体和水肿性疾病患者肾功能及激素反应性影响的首选研究工具。此外，该模型是模拟失重状态的合适工具。
