体内超声暴露后的姐妹染色单体交换与增殖模式。
Sister chromatid exchange and proliferation pattern after ultrasound exposure in vivo.
作者信息
Becher R, Zimmer G, Schmidt C G, Sandberg A A
出版信息
Am J Hum Genet. 1983 Sep;35(5):932-7.
The sister chromatid exchange (SCE) frequency and cell-cycle specific metaphase patterns were investigated in PHA-stimulated lymphocytes in vitro after in vivo exposure of 15 patients to diagnostic ultrasound. No significant differences were found in SCE rates before and after ultrasound exposure. The evaluation of cell-cycle specific metaphase patterns, differentiating cells which passed one, two, or more cell cycles, gave no evidence for a cell-growth inhibitory effect. Since SCE is regarded as a highly sensitive method for the detection of mutagenic effects, our data confirm previous reports on the genetic safety of diagnostic ultrasound.
在15名患者体内暴露于诊断性超声后，对体外PHA刺激的淋巴细胞中的姐妹染色单体交换（SCE）频率和细胞周期特异性中期模式进行了研究。超声暴露前后的SCE率未发现显著差异。对细胞周期特异性中期模式的评估，区分经过一个、两个或更多细胞周期的细胞，没有发现细胞生长抑制作用的证据。由于SCE被认为是检测诱变作用的一种高度敏感的方法，我们的数据证实了先前关于诊断性超声遗传安全性的报道。
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