健康志愿者摄入乙醇对丙吡胺消除的影响。

Effect of ethanol intake on disopyramide elimination by healthy volunteers.

作者信息

Olsen H, Bredesen J E, Lunde P K

出版信息

Eur J Clin Pharmacol. 1983;25(1):103-5. doi: 10.1007/BF00544024.

Abstract

The effect of ethanol intake on disopyramide elimination was examined in an open crossover study in six healthy volunteers. No effect of ethanol on the elimination half-life or total body clearance of disopyramide was found, although it did decrease the percentage of mono-N-dealkylated disopyramide excreted in the urine (p less than 0.05) as well as the relative metabolic clearance of disopyramide (p less than 0.05). The renal clearance of disopyramide was increased by 19 +/- 16% (p less than 0.05) in subjects in whom ethanol caused a diuresis.

摘要

在一项针对6名健康志愿者的开放性交叉研究中，检测了乙醇摄入对丙吡胺消除的影响。未发现乙醇对丙吡胺的消除半衰期或全身清除率有影响，尽管它确实降低了尿液中排泄的单-N-去烷基丙吡胺的百分比（p<0.05）以及丙吡胺的相对代谢清除率（p<0.05）。在乙醇导致利尿的受试者中，丙吡胺的肾清除率增加了19±16%（p<0.05）。