通过氟-19核磁共振对兔脑内氟化麻醉剂进行无创观察。

Noninvasive observations of fluorinated anesthetics in rabbit brain by fluorine-19 nuclear magnetic resonance.

作者信息

Wyrwicz A M, Pszenny M H, Schofield J C, Tillman P C, Gordon R E, Martin P A

出版信息

Science. 1983 Oct 28;222(4622):428-30. doi: 10.1126/science.6623084.

Abstract

Fluorinated anesthetics were observed noninvasively in the brain of intact rabbits with fluorine-19 nuclear magnetic resonance spectroscopy. High-resolution fluorine-19 spectra of halothane, methoxyflurane, and isoflurane were obtained with a surface coil centered over the calvarium. Elimination of halothane from the brain was also monitored by this technique. Residual fluorine-19 signals from halothane (or a metabolite) could be detected as long as 98 hours after termination of anesthesia. These observations demonstrate the feasibility of using this technique to study the fate of fluorinated anesthetics in live mammals.

摘要

利用氟-19核磁共振波谱法对完整家兔大脑中的含氟麻醉剂进行了无创观察。通过置于颅盖上方的表面线圈获得了氟烷、甲氧氟烷和异氟烷的高分辨率氟-19光谱。该技术还监测了氟烷从大脑中的消除情况。在麻醉结束后长达98小时仍可检测到来自氟烷（或其代谢物）的残留氟-19信号。这些观察结果证明了使用该技术研究含氟麻醉剂在活体哺乳动物体内转归的可行性。