White L, McCourt B A, Isaacs H, Siegel S E, Stowe S M, Higgins G R
Am J Pediatr Hematol Oncol. 1983 Fall;5(3):251-7.
A retrospective analysis of 125 consecutive cases of Hodgkin's disease, seen at a pediatric institution, was conducted and 28 patients under the age of 7 years (young children) were selected for comparison with a control population, aged 7 or more years. Male to female ratios were: young children, 4.6:1 vs. 1.2:1 for the controls. Symptoms at diagnosis were present in 20% of patients under age 7 and in 42% of the others. Limited Hodgkin's disease (stages I and IIA) was found in 57% of young children and in 33% of the controls, while advanced disease (stages IIIB and IV) was diagnosed in 12% of young children and in 38% of the others. Histologic types differed as follows: the young group--lymphocyte predominance (LP) 21%, nodular sclerosis (NS) 50%, mixed cellularity (MC) 29%, and lymphocyte depletion (LD) 5%, vs. the controls--LP 5%, NS 73%, MC 17%, and LD 5%. Hodgkin's disease in the young child differs from that in older populations and appears to have a favorable distribution of prognostic criteria.
对一家儿科机构连续收治的125例霍奇金病患者进行了回顾性分析，并选取了28例7岁以下的患儿（幼儿）与7岁及以上的对照人群进行比较。男女比例分别为：幼儿组4.6:1，对照组1.2:1。7岁以下患者中20%在诊断时有症状，其他患者中这一比例为42%。57%的幼儿为局限性霍奇金病（I期和IIA期），对照组中这一比例为33%；12%的幼儿被诊断为晚期疾病（IIIB期和IV期），其他患者中这一比例为38%。组织学类型差异如下：幼儿组——淋巴细胞为主型（LP）21%，结节硬化型（NS）50%，混合细胞型（MC）29%，淋巴细胞消减型（LD）5%；对照组——LP 5%，NS 73%，MC 17%，LD 5%。幼儿霍奇金病与年长人群的不同，似乎具有预后标准的有利分布。
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