西咪替丁对甲苯磺丁脲动力学的影响。
The effect of cimetidine on tolbutamide kinetics.
作者信息
Dey N G, Castleden C M, Ward J, Cornhill J, McBurney A
出版信息
Br J Clin Pharmacol. 1983 Oct;16(4):438-40. doi: 10.1111/j.1365-2125.1983.tb02192.x.
Abstract
Although possible on theoretical grounds, no interaction between cimetidine and tolbutamide could be demonstrated in ten healthy volunteers. The plasma tolbutamide concentrations over 12 h following 0.5 g orally were essentially the same before and after 1 and 7 days cimetidine (400 mg twice daily).
摘要
虽然从理论上来说有可能，但在10名健康志愿者身上未证实西咪替丁与甲苯磺丁脲之间存在相互作用。口服0.5克甲苯磺丁脲后12小时内的血浆甲苯磺丁脲浓度，在服用西咪替丁（每日两次，每次400毫克）1天及7天后与用药前基本相同。
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