[芳氧基和芳硫基烷基胺类降血脂药]
[Aryloxy- and arylthioalkylamine hypolipidemic agents].
作者信息
Duranti E, Bonifazi P, Salvatori A, Balsamini C, Peruzzi G, Cantoni O
出版信息
Farmaco Sci. 1983 Sep;38(9):664-71.
PMID:6641932
Abstract
Aryloxy and arylthioalkylamines related respectively to clofibrate and 2-(3,5-di-t-butyl-4-hydroxyphenylthio)hexanoic acid, a derivative of an active probucol metabolite, were prepared and pharmacologically screened as hypolipidemic substances. Some of them showed interesting antilipemic activity but also, unfortunately, high acute toxicity.
摘要
制备了分别与氯贝丁酯和一种活性普罗布考代谢物衍生物2-(3,5-二叔丁基-4-羟基苯硫基)己酸相关的芳氧基和芳硫基烷基胺，并作为降血脂物质进行了药理筛选。其中一些显示出有趣的抗血脂活性，但不幸的是，也具有高急性毒性。
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[Aryloxy- and arylthioalkylamine hypolipidemic agents].[芳氧基和芳硫基烷基胺类降血脂药]
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