[Placental passage of nalidixic acid (Negram) and pharmacokinetic studies in the newborn infant].

Nalidixic acid and hydroxynalidixic acid penetrate the placenta during labour. During the first 24 h of life the serum concentrations of nalidixic acid and nalidixic acid plus hydroxynalidixic acid decline slowly and show individual differences. The changed kinetic parameter in the newborn, especially the delayed elimination of nalidixic acid as well as nalidixic acid plus hydroxynalidixic acid lead to the consequence of recommendation of a very strong therapeutic indication in the peripartal period.