超致死剂量辐射及环境温度变化对小鼠尾骨生长的短期影响。
The short term effects of a supra-lethal dose of irradiation and changes in the environmental temperature on the growth of tail bones of the mouse.
作者信息
Al-Hilli F, Wright E A
出版信息
Br J Exp Pathol. 1983 Dec;64(6):684-92.
The growth and histological features of the tail vertebrae of young mice (31 day old) were observed for 48 h after transference from a cold (8 degrees) to a hot (33 degrees) environment. Some mice received a massive (5000 rad) dose of X-ray to the tail. Less than 2 h after housing the animals in the heat there was a period of very rapid growth lasting 12 h after which time growth slowed but was still much greater than the animals in the cold. Animals whose tails were irradiated (and also put in the heat) showed the same rapid growth for 12 h but after this growth ceased. Evidence is provided which shows that the initial rapid growth in the heat is due to an abnormal increase in the linear dimensions of the hypertrophic cells of the growth plate. This is most marked in the hot-irradiated animals.
在将幼鼠（31日龄）从寒冷（8摄氏度）环境转移到炎热（33摄氏度）环境后，对其尾椎骨的生长和组织学特征进行了48小时的观察。一些小鼠的尾巴接受了大剂量（5000拉德）的X射线照射。将动物置于热环境中不到2小时后，出现了一段持续12小时的非常快速的生长时期，之后生长速度减慢，但仍远高于处于寒冷环境中的动物。尾巴接受过照射（并且也置于热环境中）的动物在12小时内表现出相同的快速生长，但在此之后生长停止。有证据表明，热环境中最初的快速生长是由于生长板肥大细胞的线性尺寸异常增加所致。这在热照射的动物中最为明显。
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