棘孢链霉菌原生质体将三奥菌素转化为醌霉素。

Conversion of triostins to quinomycins by protoplasts of Streptomyces echinatus.

作者信息

Cornish A, Waring M J, Nolan R D

出版信息

J Antibiot (Tokyo). 1983 Dec;36(12):1664-70. doi: 10.7164/antibiotics.36.1664.

DOI:10.7164/antibiotics.36.1664

Abstract

Protoplasts of Streptomyces echinatus have been used to investigate the biosynthesis of echinomycin (quinomycin A). It has been shown that this organism has the capacity to convert a series of triostins to the corresponding quinomycins by a mechanism involving methylation. Evidence is presented which suggests that triostin A is the natural precursor of echinomycin. Conversion of tetra-N-demethyl analogues of triostin A to corresponding analogues of echinomycin was not detected.

摘要

棘孢链霉菌的原生质体已被用于研究棘霉素（醌霉素A）的生物合成。结果表明，该生物体有能力通过一种涉及甲基化的机制将一系列曲古抑菌素转化为相应的醌霉素。有证据表明曲古抑菌素A是棘霉素的天然前体。未检测到曲古抑菌素A的四-N-去甲基类似物向棘霉素相应类似物的转化。