暴露于高环境温度下的大鼠肝脏微粒体混合功能氧化酶
Hepatic microsomal mixed-function oxidases in rats exposed to high ambient temperature.
作者信息
Pachecka J, Kobylińska K, Miaskiewicz H, Bicz W
出版信息
Acta Physiol Pol. 1983 Sep-Dec;34(5-6):563-8.
PMID:6679992
Abstract
Exposure of rats for 3 h or 6h to 28 degrees C or 37 degrees C led to changes in mixed-function oxidases in liver microsomes as compared with 21 degrees C. The complex pattern of the behaviour of the activities of aniline hydroxylase, 4-nitroanisole-O-demethylase, aminopyrine N-demethylase and NADH: cytochrome c oxidoreductase was not related to the observed decrease of cytochrome P-450 and cytochrome b5 contents.
摘要
与21摄氏度相比，将大鼠暴露于28摄氏度或37摄氏度3小时或6小时会导致肝微粒体中混合功能氧化酶发生变化。苯胺羟化酶、4-硝基苯甲醚-O-脱甲基酶、氨基比林N-脱甲基酶和NADH：细胞色素c氧化还原酶活性的复杂变化模式与观察到的细胞色素P-450和细胞色素b5含量的降低无关。
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