绒毛膜癌、甲状腺毒症与克兰费尔特综合征。

Choriocarcinoma, thyrotoxicosis, and the Klinefelter syndrome.

作者信息

Schimke R N, Madigan C M, Silver B J, Fabian C J, Stephens R L

出版信息

Cancer Genet Cytogenet. 1983 May;9(1):1-7. doi: 10.1016/0165-4608(83)90018-3.

Abstract

A patient with the combined features of Klinefelter syndrome, thyrotoxicosis and a primary mediastinal choriocarcinoma is reported. Review of the literature reveals that extragonadal germ cell tumors appear to be significantly associated with the Klinefelter syndrome. The reason for this is presently unclear but may involve an unusual propensity of the extragonadal aneuploid germ cell to undergo malignant degeneration.

摘要

本文报告了一例患有克兰费尔特综合征、甲状腺毒症和原发性纵隔绒毛膜癌综合特征的患者。文献回顾显示，性腺外生殖细胞肿瘤似乎与克兰费尔特综合征显著相关。其原因目前尚不清楚，但可能涉及性腺外非整倍体生殖细胞发生恶性变性的异常倾向。