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[猫尾状核活动的昼夜波动及其对精神药物的敏感性]

[Diurnal fluctuations in the activity of the caudate nucleus and its sensitivity to psychotropic agents in cats].

作者信息

Arushanian E B, Pavlov V D

出版信息

Biull Eksp Biol Med. 1983 Jul;96(7):69-72.

PMID:6683576
Abstract

Restraining function of the caudate nucleus in cats is less pronounced and amphetamine-induced stereotypy is more demonstrable at night time than at day time. Amphetamine reduces caudate activity also more markedly at night. Haloperidol, on the contrary, decreases more significantly the thresholds of arrest reaction induced by stimulation of the caudate nucleus and abolishes amphetamine-induced stereotypy at day time. The data obtained might be explained by more appreciable accumulation of nigro-strial dopamine by cats at dark time.

摘要

猫尾状核的抑制功能在夜间不如白天明显,且夜间苯丙胺诱导的刻板行为比白天更易表现出来。苯丙胺在夜间也更显著地降低尾状核活动。相反,氟哌啶醇在白天更显著地降低由尾状核刺激诱导的停止反应阈值,并消除苯丙胺诱导的刻板行为。所获得的数据可能是由于猫在黑暗时期黑质-纹状体多巴胺积累更明显所致。

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