Vectorial release of sulfoconjugates in the vascularly perfused mouse small intestine.

Sulfoconjugates are formed from various xenobiotics and drugs in the vascularly perfused mouse small intestine. They can be grouped according to the sidedness of their release from the epithelium. Conjugates of paracetamol and salicylamide, like 1-naphthol-sulfate, are released exclusively into the vascular medium, whereas those of diethylstilbestrol, ethinyl-estradiol and isoprenaline appear only in the luminal perfusion medium. It is concluded from these results that selective anion transport systems for sulfoconjugates exist in the brush-border membrane as well as in the basolateral membrane of the enterocyte.