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士的宁消除了七鳃鳗在虚构运动期间的交替运动输出。

Strychnine eliminates alternating motor output during fictive locomotion in the lamprey.

作者信息

Cohen A H, Harris-Warrick R M

出版信息

Brain Res. 1984 Feb 13;293(1):164-7. doi: 10.1016/0006-8993(84)91464-1.

DOI:10.1016/0006-8993(84)91464-1
PMID:6704713
Abstract

The motor program for swimming in the lamprey includes rhythmic bursting of motoneurons with output from the two sides of a spinal segment alternating strictly out of phase. This motor program can be observed in vitro in the isolated spinal cord. Addition of strychnine (5-10 microM) can selectively eliminate the alternation between sides without blocking the temporal pattern of bursting on each side. This result suggests that temporal bursting on the right and left sides of the spinal cord is generated by independent neuronal oscillators, while the alternation between the two sides results from crossed inhibitory coupling between these oscillators.

摘要

七鳃鳗游泳的运动程序包括运动神经元的节律性爆发,脊髓节段两侧的输出严格异相交替。这种运动程序可以在离体脊髓的体外实验中观察到。添加士的宁(5-10微摩尔)可以选择性地消除两侧之间的交替,而不会阻断每一侧爆发的时间模式。这一结果表明,脊髓左右两侧的时间性爆发是由独立的神经元振荡器产生的,而两侧之间的交替是由这些振荡器之间的交叉抑制性耦合导致的。

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